Temporal horn volume expansion is a sensitive biomarker of Alzheimer's disease (AD) progression over time, accurately discriminating between patients with an underlying disease process from normal elderly controls (NECs).
Presented here at the Alzheimer's Disease International 26th International Conference, research by Amanda Khan, MSc, University of Western Ontario, London, Canada, showed only patients with an underlying disease process, including mild cognitive impairment (MCI) and AD, had evidence of significant enlargement in the temporal horn region of the ventricular system during a 2-year time span compared with NECs.
Changes in both total ventricular and total horn volume were adjusted by age, sex, education, the presence of at least 1 ApoE-4 allele, and the Alzheimer's Disease Assessment Scale–cognitive subscale score.
Dr. Korczyn noted that changes in temporal horn volume would also allow researchers to objectively monitor response to treatment, which is not currently possible using standardized cognitive tests.
"If we can identify changes early, before patients have clinical manifestations of AD, this is the window of opportunity where we may be able to slow down these changes with treatment."
source:medscape
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