Doripenem belongs to the carbapenem class of antimicrobials. Doripenem exerts its bactericidal activity by inhibiting bacterial cell wall biosynthesis. Doripenem inactivates multiple essential penicillin-binding proteins (PBPs) resulting in inhibition of cell wall synthesis with subsequent cell death. In E. coli and P. aeruginosa, doripenem binds to PBP 2, which is involved in the maintenance of cell shape, as well as to PBPs 3 and 4.
Doripenem is specifically indicated for the treatment of the following infections caused by designated susceptible bacteria: complicated intra-abdominal infections and complicated urinary tract infections, including pyelonephritis.
source:centerwatch
Doripenem is specifically indicated for the treatment of the following infections caused by designated susceptible bacteria: complicated intra-abdominal infections and complicated urinary tract infections, including pyelonephritis.
source:centerwatch
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