A combination of 4 blood proteins may serve as biomarkers to help clinicians distinguish patients with asthma from those with chronic obstructive pulmonary disease (COPD), Australian researchers report. These proteins have "the potential to be a valuable tool in the clinical diagnosis of respiratory disease,"
The biomarkers were identified through proteomics, which "can simultaneously identify multiple proteins associated with different disease states and potentially discover novel proteins not previously associated with particular disease states," the authors explain.
The findings suggest that those 4 proteins — ceruloplasmin, haptoglobin, hemopexin, and α-2-macroglobulin — can be used in combination to identify patients with asthma and COPD, the authors write. For example, in the younger patients, the combination of ceruloplasmin and haptoglobin was best for discriminating between asthmatic and healthy control patients, whereas in the older patients, haptoglobin and hemopexin were more effective.
source:medscape
The biomarkers were identified through proteomics, which "can simultaneously identify multiple proteins associated with different disease states and potentially discover novel proteins not previously associated with particular disease states," the authors explain.
The findings suggest that those 4 proteins — ceruloplasmin, haptoglobin, hemopexin, and α-2-macroglobulin — can be used in combination to identify patients with asthma and COPD, the authors write. For example, in the younger patients, the combination of ceruloplasmin and haptoglobin was best for discriminating between asthmatic and healthy control patients, whereas in the older patients, haptoglobin and hemopexin were more effective.
source:medscape
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