A variant of HMGA1 occurs significantly more often in patients with type 2 diabetes mellitus (DM) who are of white European heritage than in control patients.
The variant, designated IVS5-13insC, impairs function of the HMGA1 protein, a cofactor for gene activation that regulates insulin-receptor gene (INSR) expression.
source:medscape
The variant, designated IVS5-13insC, impairs function of the HMGA1 protein, a cofactor for gene activation that regulates insulin-receptor gene (INSR) expression.
The presence of these variants suggests several potential clinical uses:
- as early predictive markers of insulin resistance and type 2 DM;
- to predict response to therapies such as insulin sensitizers;
- to predict the clinical course of type 2 DM, such as the likelihood of macro- and microvascular complications; and
- to indicate patients with type 2 DM for whom targeted therapy could involve agents that upregulate HMGA1 expression.
source:medscape
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